With Microsoft App-V 4.5, and with SoftGrid 4.2 along with the MSI utility , we now have the ability to create and distribute standalone virtual apps that require no server or streaming infrastructure whatsoever. While this gives tremendous flexibility
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Read the complete post at http://blogs.technet.com/softgrid/archive/2009/01/05/msi-based-virtual-apps-may-only-create-quick-launch-icons-for-the-account-used-to-installed-it.aspx