Some years ago, at a former job, I had the role of scripting guy. I wrote scripts for just about everything that could be automated by scripting. Active Directory, SQL, event logs, registry management, file and folder editing or data mining, web reports...
Here's one that will scour your domain for disabled computer accounts and delete them. It then sends an e-mail report to list which computers were deleted to whomever you choose. Remember to edit the settings near the top to suit your environment. Enjoy...